Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

Authors :: Radivoj Jadrić
Sabaheta Hasić
Emina Kiseljaković
Jovan Radovanović
Emina Ićindić-Nakaš
Mira Winterhalter-Jadrić
Source :: Biomolecules & Biomedicine, Vol 6, Iss 4 (2006)
Publication Year :: 2006
Publisher :: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2006.
Abstract: The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.