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Acute hyponatriemia in a patient with schizophrenia: Case report water intoxication induced acute hyponatriemia
- Source :
- Serbian Journal of Anesthesia and Intensive Therapy, Vol 41, Iss 3-4, Pp 77-80 (2019)
- Publication Year :
- 2019
- Publisher :
- Serbian Society of Anesthesiologists and Intensivists, 2019.
-
Abstract
- Introduction: Hyponatremia is defined as a serum sodium level higher than 135 mmol/L, while serum sodium level lower 125 mmol/L is considered as severe hyponatremia and can lead to coma, death, rhabdomyolysis, and neurologic damage. Case report: We present the case of a 34 year old male with history of schizophrenia with multiple seizures followed by loss of consciousness after intake of 6 liters of water. Diagnostic CT scan revealed cerebral edema. Laboratory tests revealed severe hyponatremia (109 mmol/l), hypokalemia and hypocalcemia. The patient was treated with 10% hypertonic NaCl 120 ml per day, 7.4% KCl and calcium gluconate. He was sedated and mechanically ventilated. Antiedematous therapy with mannitol 20% was started. The biochemical results improved slowly with gradual correction of the sodium level: 112 mmol/l, 119 mmol/l and 127 mmol/l respectively. CT scan showed cerebral edema regression was showed on repeated brain scan. On the 6th day sodium level was 131 mmol/l, and the patient was awake, oriented and extubated. Discussion: Psychogenic polydipsia occurs in 20% of the psychiatric patients which could lead to severe hyponatremia. Second generation antipsychotics intake could also lead to severe hyponatremia. According guidelines hyponatremia treatment consists of hypertonic NaCl 3% 150 ml infusion and frequent sodium levels measurements. The sodium level correction should be gradual and should not exceed more than 10 mmol/l for the first 24 hours neither more than 8 mmol/L for every next 24 hours. Conclusion: In our patient, serum sodium level correction was successfully and safely performed with hypertonic saline (NaCl 10%) in absence of hypertonic NaCl 3%. Strict control of serum sodium levels is a must in order to avoid osmotic demielinisation and rhabdomyolysis.
- Subjects :
- hyponatremia
water intoxication
hypertonic saline
Anesthesiology
RD78.3-87.3
Subjects
Details
- Language :
- English, Serbian
- ISSN :
- 2466488X
- Volume :
- 41
- Issue :
- 3-4
- Database :
- Directory of Open Access Journals
- Journal :
- Serbian Journal of Anesthesia and Intensive Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.493f3e8c1a99444883ab9488fe6e70f0
- Document Type :
- article