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Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Authors :
Timur Sh Atabaev
Jong Ho Lee
Yong Cheol Shin
Dong-Wook Han
Ki Seok Choo
Ung Bae Jeon
Jae Yeon Hwang
Jeong A. Yeom
Hyung-Kook Kim
Yoon-Hwae Hwang
Source :
Nanomaterials, Vol 7, Iss 2, p 35 (2017)
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging.

Details

Language :
English
ISSN :
20794991
Volume :
7
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Nanomaterials
Publication Type :
Academic Journal
Accession number :
edsdoj.496ffb1b40444d5b878fac8dbb25712d
Document Type :
article
Full Text :
https://doi.org/10.3390/nano7020035