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Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells
- Source :
- Molecular & Cellular Oncology, Vol 4, Iss 3 (2017)
- Publication Year :
- 2017
- Publisher :
- Taylor & Francis Group, 2017.
-
Abstract
- Mitotic catastrophe is an oncosuppressive mechanism that targets cells experiencing defective mitoses via the activation of specific cell cycle checkpoints, regulated cell death pathways and/or cell senescence. This prevents the accumulation of karyotypic aberrations, which otherwise may drive oncogenesis and tumor progression. Here, we summarize experimental evidence confirming the role of caspase 2 (CASP2) as the main executor of mitotic catastrophe, and we discuss the signals that activate CASP2 in the presence of mitotic aberrations. In addition, we summarize the main p53-dependent and -independent effector pathways through which CASP2 limits chromosomal instability and non-diploidy, hence mediating robust oncosuppressive functions.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 4
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.49ec480e6e66465e960ab55bdb09990f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2017.1299274