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The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia
- Source :
- Korean Journal of Anesthesiology, Vol 68, Iss 3, Pp 267-273 (2015)
- Publication Year :
- 2015
- Publisher :
- Korean Society of Anesthesiologists, 2015.
-
Abstract
- BackgroundThe purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl.MethodsIn this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated.ResultsThe incidence of PONV was significantly lower in the PD group compared with the D group during the 0-24 hours (43 vs. 59%) and 0-48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6-24 hours after surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0-6 hours after surgery (13.1 vs. 24.5%) (P < 0.05).ConclusionsPalonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl.
Details
- Language :
- English
- ISSN :
- 20056419 and 20057563
- Volume :
- 68
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Korean Journal of Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4ad9b90590f54625a2e7dcb5ce0564c9
- Document Type :
- article
- Full Text :
- https://doi.org/10.4097/kjae.2015.68.3.267