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Laparoscopic versus open treatment of gallbladder cancer: A systematic review and meta-analysis
- Source :
- Journal of Minimal Access Surgery, Vol 14, Iss 3, Pp 185-191 (2018)
- Publication Year :
- 2018
- Publisher :
- Wolters Kluwer Medknow Publications, 2018.
-
Abstract
- Background: The aim of this review was to evaluate the effect of laparoscopic surgery on the treatment of patients with gallbladder cancer (GBC). Methods: A comprehensive search of Medline and Cochrane Library was conducted to identify relevant articles. A meta-analysis was subsequently performed. Results: A total of 20 studies including 1217 patients met the inclusion criteria. The meta-analysis showed that the 5-year survival rate was significant higher in laparoscopic group than open group (48.4% vs. 38.5%; odds ratio [OR], 1.63; 95% confidence interval [CI], 1.22–2.19; P = 0.001). Although the scar recurrence rate was significant higher in laparoscopic group than open group (7.1% vs. 4.0%; OR, 2.10; 95% CI, 1.11–3.96; P = 0.02), the overall recurrence rates between two groups were not significant different (44.8% vs. 42.2%; OR, 0.86; 95% CI, 0.64–1.14; P = 0.29). In addition, compared with open extended cholecystectomy (EC), laparoscopic EC (LEC) was associated with less intraoperative blood loss, shorter post-operative hospital stays and insignificant less complication rate (10.0% vs. 18.3%; OR, 0.51; 95% CI, 0.15–1.73; P = 0.28). Conclusion: Laparoscopic simple cholecystectomy does not lead to a worse prognosis when applied on patients with GBC. LEC can be performed in specialised expert centres on elective patients.
Details
- Language :
- English
- ISSN :
- 09729941 and 19983921
- Volume :
- 14
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Minimal Access Surgery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4b2a4281123d4afdac81f1e39c490457
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/jmas.JMAS_223_16