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Activation of Wnt/β-catenin pathway in monocytes derived from chronic kidney disease patients.

Authors :
Heevy Abdulkareem Musa Al-Chaqmaqchi
Ali Moshfegh
Elham Dadfar
Josefin Paulsson
Moustapha Hassan
Stefan H Jacobson
Joachim Lundahl
Source :
PLoS ONE, Vol 8, Iss 7, p e68937 (2013)
Publication Year :
2013
Publisher :
Public Library of Science (PLoS), 2013.

Abstract

Patients with chronic kidney disease (CKD) have significantly increased morbidity and mortality resulting from infections and cardiovascular diseases. Since monocytes play an essential role in host immunity, this study was directed to explore the gene expression profile in order to identify differences in activated pathways in monocytes relevant to the pathophysiology of atherosclerosis and increased susceptibility to infections. Monocytes from CKD patients (stages 4 and 5, estimated GFR

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
7
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.4b9451f2413145afad9abea6b573f934
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0068937