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The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

Authors :
Katrina A. Button-Simons
Sudhir Kumar
Nelly Carmago
Meseret T. Haile
Catherine Jett
Lisa A. Checkley
Spencer Y. Kennedy
Richard S. Pinapati
Douglas A. Shoue
Marina McDew-White
Xue Li
François H. Nosten
Stefan H. Kappe
Timothy J. C. Anderson
Jeanne Romero-Severson
Michael T. Ferdig
Scott J. Emrich
Ashley M. Vaughan
Ian H. Cheeseman
Source :
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Button-Simons et al. report on two different genetic crosses of Plasmodium falciparum derived from Asian and African origin parasites, and generate large numbers of recombinant progeny. These crosses are characterized and have the potential to map biologically important traits across parasite genomes.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.4b96c353972642afa3c35313f59f6b9c
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-021-02210-1