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Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer

Authors :
Xintong Zhou
Xiaomin Wang
Qi Sun
Wenfeng Zhang
Cun Liu
Wenzhe Ma
Changgang Sun
Source :
Biomedicine & Pharmacotherapy, Vol 151, Iss , Pp 113096- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.

Details

Language :
English
ISSN :
07533322
Volume :
151
Issue :
113096-
Database :
Directory of Open Access Journals
Journal :
Biomedicine & Pharmacotherapy
Publication Type :
Academic Journal
Accession number :
edsdoj.4ba2ce1aebc24a20a6a3f755f2e3ba5d
Document Type :
article
Full Text :
https://doi.org/10.1016/j.biopha.2022.113096