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Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation

Authors :
Po-Ting Liu
Brandon F. Keele
Peter Abbink
Noe B. Mercado
Jinyan Liu
Esther A. Bondzie
Abishek Chandrashekar
Erica N. Borducchi
Joseph Hesselgesser
Michael Mish
Gregory Chin
Elena Bekerman
Romas Geleziunas
Dan H. Barouch
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The origin and nature of rebound HIV-1 virus following antiretroviral therapy (ART) discontinuation still remains unclear. Here, Liu et al. suggest that intact proviral DNA in peripheral blood and lymph node mononuclear cells during ART suppression likely is the source of viral rebound following ART discontinuation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4bcf043d109d4ee280c833a2bd8a8741
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19254-2