Histological evaluation of gingival enlargement response to oral folic acid administration in rabbit

Aims of the study: to clarify the clinical and histological evaluation of the oral folic acid effect on reduction of drug induced gingival enlargement. Materials and methods: The study was carried out in the college of dentistry /university of Mosul on twelve white local male Rabbits with gingival enlargement weights between (900 g±1.250g). six rabbits considered a control group and the other six rabbits considered a treated group which taking 15 mg orally folic acid once daily for about 14 days then depth of gingival sulcus(gingival pocket) evaluated clinically by a periodontal probe and euthaniused for histological examination. Result: Clinically: after 14 days of drug administration, there is a high clinical difference between two group (mean +- SD), control group have (3-5mm) of gingival enlargement and the experimental group have (1-3 mm) of gingival enlargement. The Histological finding show significant differences in the form of gingival sulcus depth(gingival pocket) and inflammatory cell infiltration and connective tissue in the control group and experimental group. Conclusion: the effect of oral administration of folic acid have higher evaluation on reducing the drug induced gingival enlargement in rabbit