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Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
- Source :
- Data in Brief, Vol 7, Iss , Pp 257-281 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. Keywords: Synthesis, Inhibitors, Hedgehog acyltransferase, Conformation
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 7
- Issue :
- 257-281
- Database :
- Directory of Open Access Journals
- Journal :
- Data in Brief
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4bfe980dcf9a43e8805f3661c29e6981
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.dib.2016.02.012