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Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Authors :
Stefan Antonowicz
Zsolt Bodai
Tom Wiggins
Sheraz R. Markar
Piers R. Boshier
Yan Mei Goh
Mina E. Adam
Haonan Lu
Hiromi Kudo
Francesca Rosini
Robert Goldin
Daniela Moralli
Catherine M. Green
Chris J. Peters
Nagy Habib
Hani Gabra
Rebecca C. Fitzgerald
Zoltan Takats
George B. Hanna
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4cb39fcd5d245a5814461336da92aeb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21800-5