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Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC

Authors :
Yunyi Wang
Aili Fan
Ryan D. Cohen
Guilherme Dal Poggetto
Zheng Huang
Haifeng Yang
Gary E. Martin
Edward C. Sherer
Mikhail Reibarkh
Xiao Wang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The inability to distinguish two-bond from long-range HMBC correlation has historically impeded NMR structure elucidation. Here the authors developed a practical iHMBC methodology utilizing accurate isotope shift measurement to overcome this limitation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4d1a5021e853492f8d7a31ff5b593c3d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-37289-z