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The clinicopathological relevance of uniform CD56 expression in anaplastic large cell lymphoma: a retrospective analysis of 18 cases

The clinicopathological relevance of uniform CD56 expression in anaplastic large cell lymphoma: a retrospective analysis of 18 cases

Authors :
Bao-Hua Yu
Yan Zhang
Tian Xue
Ruo-Hong Shui
Hong-Fen Lu
Xiao-Yan Zhou
Xiong-Zeng Zhu
Xiao-Qiu Li
Source :
Diagnostic Pathology, Vol 16, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Anaplastic large cell lymphoma (ALCL) with uniform CD56 expression is a rare condition, that has been described in limited literature, and its clinicopathological features have not yet been well illustrated. The aim of our study was to fully investigate the clinical, histological, immunohistochemical and molecular features of CD56+ ALCL. Methods The clinical and histological characteristics of CD56+ ALCL cases were retrospectively evaluated. The immunohistochemical phenotype, status of Epstein-Barr virus (EBV) and T-cell receptor (TCR) gene rearrangement were examined. Overall survival was also analyzed. Results Eighteen (5.8%) cases with diffuse CD56 expression were identified out of 313 archived ALCL cases with CD56 test. CD56 expression was significantly higher in ALK+ systemic ALCLs (sALCLs) (13/64, 20.3%) than in ALK- sALCLs (3/101, 3.0%) (p

Details

Language :
English
ISSN :
17461596
Volume :
16
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Diagnostic Pathology
Publication Type :
Academic Journal
Accession number :
edsdoj.4e1cb56cbed34f698d2e509c3f1b26d9
Document Type :
article
Full Text :
https://doi.org/10.1186/s13000-020-01059-y