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Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4e2ac2ef78f74d52bdfce93123908f3a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-23649-0