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Clinical efficacy of Conbercept combined with different treatment modalities in patients with neovascular glaucoma
- Source :
- Guoji Yanke Zazhi, Vol 21, Iss 11, Pp 1865-1869 (2021)
- Publication Year :
- 2021
- Publisher :
- Press of International Journal of Ophthalmology (IJO PRESS), 2021.
-
Abstract
- AIM: To investigate the impact of intravitreal conbercept injection on the aqueous humor levels of vascular endothelial growth factor(VEGF), interleukin-6(IL-6)and interleukin-8(IL-8)in patients diagnosed with neovascular glaucoma(NVG), and to evaluate the efficacy of conbercept in combination with different surgical modalities.METHODS: This study was conducted as a retrospective, case series investigation. A total of 102 patients(102 eyes)diagnosed with NVG from Jan. 2019 to Feb. 2020 were enrolled and randomized to trabeculectomy group(50 eyes of 50 cases)or EX-PRESS drain implantation group(52 eyes of 52 cases)3-5d after conbercept injections. The concentrations of VEGF, IL-6 and IL-8 in aqueous humor were determined by enzyme-linked immunosorbent assay(ELISA). The therapeutic efficacies of different surgical modalities were evaluated and compared by status of iris neovascularization, changes in postoperative intraocular pressure(IOP), improvement of visual acuity and incidence of complications.RESULTS:Decreases in aqueous humor concentrations of VEGF, IL-6 and IL-8 were observed at 3-5d after treatment of conbercept(all P
- Subjects :
- neovascular glaucoma
conbercept
intraocular pressure
il-6
il-8
Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 16725123
- Volume :
- 21
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Guoji Yanke Zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4e800c70f9df45e19a49e0ab3d38eaec
- Document Type :
- article
- Full Text :
- https://doi.org/10.3980/j.issn.1672-5123.2021.11.06