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BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists
- Source :
- Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
- Publication Year :
- 2023
- Publisher :
- BMC, 2023.
-
Abstract
- Key points TLR9 is not only a prognostic biomarker but also a potential target for B-ALL therapy. C-MYC-mediated BAX activation leads to CpG 685-induced apoptosis in B-ALL.
Details
- Language :
- English
- ISSN :
- 14795876
- Volume :
- 21
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4f394fbb7a74986b8f38af747a7f72a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12967-023-03969-z