Experimental Study of The Pharmacokinetics of Cefotaxime with Joint Administration of Drugs with Hyaluronidase Activity

It Is shown that the preliminary administration of drugs that promote the flow of antibiotics into the lymphatic system increases the clinical effectiveness of treatment. Currently, there is a need for experimental justification of this approach to antibacterial therapy. In this study, the effect of drugs with hyaluronidase activity on the rate of lymphatic tissue drainage and the pharmacokinetics of cefotaxime was studied. We determined the time of the removal of lymphotropic blue dye evans of the mesentery of mice when administered on the background of hyaluronidase and bovhyaluronidaze azoximer, the concentration of cefotaxime in the dynamics during the day in blood plasma of rabbits and in the blood plasma, the intestinal tissues and the liver of mice after 1.5 and 24 h after the co-administration of antibiotic with hyaluronidase and bolgelerinde anoxemia. It is found that the hyaluronidase, and bovhyaluronidaze azoximer are equieffective stimulants of lymphatic drainage of tissues. The data obtained indicate the presence of endolymphatic properties of the conductor not only on hyaluronidase, but at bovhyaluronidaze azoximer, additional properties which allow to consider it as a priority of the drug when conducting lymphotropic therapy.