Back to Search Start Over

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

Authors :
Marija Zaric
Pablo D. Becker
Catherine Hervouet
Petya Kalcheva
Andor Doszpoly
Negin Blattman
Lauren A. O’ Neill
Barbara Ibarzo Yus
Clement Cocita
Sung-Yun Kwon
Andrew H. Baker
Graham M. Lord
Linda S. Klavinskis
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.50310e1b618c4e9db13be9368bb83233
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-09969-2