Back to Search Start Over

Sustained Resolution of Nail Psoriasis Through 5 Years with Ixekizumab: A Post-Hoc analysis from UNCOVER-3

Authors :
Alexander Egeberg
Lars Erik Kristensen
Ronald Vender
Shirin Zaheri
Celine El Baou
Gaia Gallo
Elisabeth Riedl
Christopher Schuster
Source :
Acta Dermato-Venereologica, Vol 102 (2022)
Publication Year :
2022
Publisher :
Medical Journals Sweden, 2022.

Abstract

Nail psoriasis is a chronic, difficult-to-treat condition affecting almost half of patients with psoriasis. It is associated with considerable social stigma and impairment of patients’ quality of life. The aim of this study was to assess improvements in objective measures of nail psoriasis among patients from the long-term extension of the UNCOVER-3 study who received the interleukin-17A inhibitor ixekizumab and had either any degree of nail psoriasis (Nail Psoriasis Severity Index (NAPSI) >=1) or significant nail psoriasis (fingernail NAPSI ≥ 16 and ≥ 4 fingernails involved) at baseline. Efficacy outcomes reported through week 264 included the mean percentage improvements from baseline in NAPSI score and the proportion of patients achieving nail psoriasis resolution (NAPSI=0). In UNCOVER-3, 56.9% (219/385) of patients had nail psoriasis at baseline; of those, 61.2% (134/219) had significant nail psoriasis. At week 60, a total of 66.9% and 59.1% of patients with baseline nail psoriasis and significant baseline nail psoriasis, respectively, reported complete clearance of nail psoriasis, an effect which was sustained through week 264. This analysis demonstrates that continuous treatment with ixekizumab in adult patients with moderate-to-severe-psoriasis through 264 weeks was associated with improvements and clearance of fingernail psoriasis, irrespective of the severity of nail psoriasis at baseline.

Details

Language :
English
ISSN :
00015555 and 16512057
Volume :
102
Database :
Directory of Open Access Journals
Journal :
Acta Dermato-Venereologica
Publication Type :
Academic Journal
Accession number :
edsdoj.503549c24a21457fa10bb1ea616673a4
Document Type :
article
Full Text :
https://doi.org/10.2340/actadv.v102.2269