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The effects of two vitamin D regimens on ulcerative colitis activity index, quality of life and oxidant/anti-oxidant status
- Source :
- Nutrition Journal, Vol 18, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Abstract Background The optimum dosage for vitamin D supplementation has not yet been elucidated in patients with Ulcerative colitis (UC). The aim of this study was to investigate the effects of two vitamin D regimens in UC patients with vitamin D deficiency. Methods In this double blind randomized clinical trial, 50 patients with mild to moderate UC, who met inclusion criteria, received either 1000 or 2000 IU/day of vitamin D (as low dose or high dose group, respectively) for 12 weeks. Serum 25-hydroxy vitamin D (25-OHD) level, total antioxidant capacity (TAC), and Total Oxidant Status (TOS), the inflammatory bowel disease questionnaire − 9 (IBDQ-9) score and the Simple Clinical Colitis Activity Index Questionnaire (SCCAI) score were assessed before and after intervention. Results At the end of study, serum 25-OHD levels significantly increased in the high dose group (P
Details
- Language :
- English
- ISSN :
- 14752891
- Volume :
- 18
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nutrition Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5082fe4867534d738b97d3d4f44c3609
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12937-019-0441-7