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ChAdOx1 nCoV-19 (AZD1222) vaccine candidate significantly reduces SARS-CoV-2 shedding in ferrets

Authors :
Glenn A. Marsh
Alexander J. McAuley
Gough G. Au
Sarah Riddell
Daniel Layton
Nagendrakumar B. Singanallur
Rachel Layton
Jean Payne
Peter A. Durr
Hannah Bender
Jennifer A. Barr
John Bingham
Victoria Boyd
Sheree Brown
Matthew P. Bruce
Kathie Burkett
Teresa Eastwood
Sarah Edwards
Tamara Gough
Kim Halpin
Jenni Harper
Clare Holmes
William S. J. Horman
Petrus Jansen van Vuren
Suzanne Lowther
Kate Maynard
Kristen D. McAuley
Matthew J. Neave
Timothy Poole
Christina Rootes
Brenton Rowe
Elisha Soldani
Vittoria Stevens
Cameron R. Stewart
Willy W. Suen
Mary Tachedjian
Shawn Todd
Lee Trinidad
Duane Walter
Naomi Watson
Trevor W. Drew
Sarah C. Gilbert
Teresa Lambe
S. S. Vasan
Source :
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Abstract Vaccines against SARS-CoV-2 are likely to be critical in the management of the ongoing pandemic. A number of candidates are in Phase III human clinical trials, including ChAdOx1 nCoV-19 (AZD1222), a replication-deficient chimpanzee adenovirus-vectored vaccine candidate. In preclinical trials, the efficacy of ChAdOx1 nCoV-19 against SARS-CoV-2 challenge was evaluated in a ferret model of infection. Groups of ferrets received either prime-only or prime-boost administration of ChAdOx1 nCoV-19 via the intramuscular or intranasal route. All ChAdOx1 nCoV-19 administration combinations resulted in significant reductions in viral loads in nasal-wash and oral swab samples. No vaccine-associated adverse events were observed associated with the ChAdOx1 nCoV-19 candidate, with the data from this study suggesting it could be an effective and safe vaccine against COVID-19. Our study also indicates the potential for intranasal administration as a way to further improve the efficacy of this leading vaccine candidate.

Details

Language :
English
ISSN :
20590105
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
npj Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.50b66ce00589424eb554445061a67484
Document Type :
article
Full Text :
https://doi.org/10.1038/s41541-021-00315-6