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Trachylobane and kaurane diterpenes from Croton floribundus spreng

Authors :
Paula Karina S. Uchôa
José Nunes da Silva Jr.
Edilberto Rocha Silveira
Mary Anne S. Lima
Raimundo Braz-Filho
Letícia Veras Costa-Lotufo
Ana Jérsia Araújo
Manoel Odorico de Moraes
Claudia do Ó Pessoa
Source :
Química Nova, Vol 36, Iss 6, Pp 778-782 (2013)
Publication Year :
2013
Publisher :
Sociedade Brasileira de Química, 2013.

Abstract

A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.

Details

Language :
English, Spanish; Castilian, Portuguese
ISSN :
16787064 and 01004042
Volume :
36
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Química Nova
Publication Type :
Academic Journal
Accession number :
edsdoj.50cf3310d0e642d9ac888f96a32a4adb
Document Type :
article
Full Text :
https://doi.org/10.1590/S0100-40422013000600006