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Trachylobane and kaurane diterpenes from Croton floribundus spreng
- Source :
- Química Nova, Vol 36, Iss 6, Pp 778-782 (2013)
- Publication Year :
- 2013
- Publisher :
- Sociedade Brasileira de Química, 2013.
-
Abstract
- A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.
- Subjects :
- diterpenes
Croton floribundus
Euphorbiaceae
Chemistry
QD1-999
Subjects
Details
- Language :
- English, Spanish; Castilian, Portuguese
- ISSN :
- 16787064 and 01004042
- Volume :
- 36
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Química Nova
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.50cf3310d0e642d9ac888f96a32a4adb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S0100-40422013000600006