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Polycyclic aromatic hydrocarbon and its adducts in peripheral blood: Gene and environment interaction among Chinese population

Authors :
Ling Guo
Xuewei Zhang
Xinwei Li
Kai Wang
Yanhua Wang
Alimire Abulikemu
Xizi Su
Mushui Shu
Haibin Li
Shiwei Cui
Zhizhen Xu
Haoyuan Tian
Yong Niu
Huige Yuan
Zhizhou He
Xin Sun
Huawei Duan
Source :
Environment International, Vol 190, Iss , Pp 108922- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Background: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limited research on the role of the variation of metabolic enzymes in this process. Methods: We carried out a study including 752 participants, measured the concentrations of 16 kinds PAHs in both particle and gaseous phases, urinary PAHs metabolites, leukocyte BPDE-DNA adduct and serum BPDE- Albumin (BPDE-Alb) adduct, and calculated daily intake dose (DID) to assess the cumulative exposure of PAHs. We conducted single nucleotide polymorphism sites (SNPs) of metabolic enzymes, explored the exposure–response relationship between the levels of exposure and BPDE adducts using multiple linear regression models. Result: Our results indicated that an interquartile range (IQR) increase in B[a]P, PAHs, BaPeq, 1-hydroxypyrene (1-OHP), 1-hydroxynaphthalene (1-OHNap) and 2-hydroxynaphthalene (2-OHNap) were associated with 26.53 %, 24.24 %, 28.15 %, 39.15 %, 12.85 % and 14.09 % increase in leukocyte BPDE-DNA adduct (all P 0.05). Besides, we also found the polymorphism of CYP1A1(Gly45Asp), CYP2C9 (Ile359Leu), and UGT1A1(downstream) may affect BPDE adducts level. Conclusion: Our results indicated that leukocyte BPDE-DNA adduct could better reflect the exposure to PAHs. Furthermore, the polymorphism of CYP1A1, CYP2C9 and UGT1A1affected the content of BPDE adducts.

Details

Language :
English
ISSN :
01604120
Volume :
190
Issue :
108922-
Database :
Directory of Open Access Journals
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
edsdoj.5106da60d6f344bd998834f1b5a7ba4f
Document Type :
article
Full Text :
https://doi.org/10.1016/j.envint.2024.108922