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The Role of Fibrosis in Osteoarthritis Progression

The Role of Fibrosis in Osteoarthritis Progression

Authors :
Yeri Alice Rim
Ji Hyeon Ju
Source :
Life, Vol 11, Iss 1, p 3 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics include cartilage degeneration and synovial membrane inflammation. These changes in the knee joint eventually dampen the function of the joint and restrict joint movement, which eventually leads to a stage where total joint replacement is the only treatment option. While much is still unknown about the pathogenesis and progression mechanism of OA, joint fibrosis can be a critical issue for better understanding this disease. Synovial fibrosis and the generation of fibrocartilage are the two main fibrosis-related characteristics that can be found in OA. However, these two processes remain mostly misunderstood. In this review, we focus on the fibrosis process in OA, especially in the cartilage and the synovium tissue, which are the main tissues involved in OA.

Details

Language :
English
ISSN :
20751729
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Life
Publication Type :
Academic Journal
Accession number :
edsdoj.5130b31e11b94853a5baa447840711ec
Document Type :
article
Full Text :
https://doi.org/10.3390/life11010003