Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

Authors :: Shrikant B. Kokate
Katarzyna Ciuba
Vivien D. Tran
Reena Kumari
Sari Tojkander
Ulrike Engel
Konstantin Kogan
Sanjay Kumar
Pekka Lappalainen
Source :: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Publication Year :: 2022
Publisher :: Nature Portfolio, 2022.
Abstract: In this study the authors report that Caldesmon controls force-balance and architecture of stress fibers through dynamic cross-linking of actin and myosin filaments. Caldesmon depletion led to consequent problems in cell morphogenesis, motility and mechanosensing.

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