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Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET

Authors :
Franziska C. Trudzinski
Rudolf A. Jörres
Peter Alter
Julia Walter
Henrik Watz
Andrea Koch
Matthias John
Marek Lommatzsch
Claus F. Vogelmeier
Hans-Ulrich Kauczor
Tobias Welte
Jürgen Behr
Amanda Tufman
Robert Bals
Felix J. F. Herth
Kathrin Kahnert
The COSYCONET Study Group
Source :
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Abstract In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome related to extrapulmonary disorders and a pulmorbidome, referring to pulmonary disorders. The study population comprised 1044 women and 1531 men with the diagnosis of COPD from COSYCONET, among them 2175 of GOLD grades 1–4 and 400 at risk. Associations of comorbidities with mortality were studied using Cox regression analysis for men and women separately. During the follow-up (median 3.7 years) 59 women and 159 men died. In men, obesity, hypertension, coronary artery disease, liver cirrhosis, osteoporosis, kidney disease, anaemia and increased heart rate (HR) predict mortality, in women heart failure, hyperuricemia, mental disorders, kidney disease and increased HR (p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.51c621bd8e324fefa23aea0da7193a99
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-022-12828-8