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Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study

Authors :
Georgios Meletis
Areti Tychala
Georgios Ntritsos
Eleni Verrou
Filio Savvidou
Iasonas Dermitzakis
Anastasia Chatzidimitriou
Ioanna Gkeka
Barbara Fyntanidou
Sofia Gkarmiri
Alexandros T. Tzallas
Efthymia Protonotariou
Kali Makedou
Dimitrios G. Tsalikakis
Lemonia Skoura
Source :
Biomedicines, Vol 11, Iss 4, p 1143 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender, VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal–Wallis test, two-way ANOVA, Chi-square, T-test, the Mann–Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and VOC were significantly associated with hospitalization, whereas significant differences among VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient’s status at admission are subject to changes.

Details

Language :
English
ISSN :
22279059
Volume :
11
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.51fc66d86374e47966d2a98881869bc
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines11041143