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Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

Authors :
Daniel Sobral
Marta Martins
Shannon Kaplan
Mahdi Golkaram
Michael Salmans
Nafeesa Khan
Raakhee Vijayaraghavan
Sandra Casimiro
Afonso Fernandes
Paula Borralho
Cristina Ferreira
Rui Pinto
Catarina Abreu
Ana Lúcia Costa
Shile Zhang
Traci Pawlowski
Jim Godsey
André Mansinho
Daniela Macedo
Soraia Lobo-Martins
Pedro Filipe
Rui Esteves
João Coutinho
Paulo Matos Costa
Afonso Ramires
Fernando Aldeia
António Quintela
Alex So
Li Liu
Ana Rita Grosso
Luis Costa
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The genetic and microenvironmental heterogeneity of colorectal cancer is analyzed using a prospective biobank of primary and metastatic tumor tissues to highlight features of intra-tumoral heterogeneity that favor tumor progression and metastasis.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.521f8b4260d84b81a20a13cbf27320d4
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03884-x