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Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)

Authors :
Javier García-Pérez
Nerea Fernández de Larrea-Baz
Virginia Lope
Antonio J. Molina
Cristina O'Callaghan-Gordo
María Henar Alonso
Marta María Rodríguez-Suárez
Benito Mirón-Pozo
Juan Alguacil
Inés Gómez-Acebo
Nieves Ascunce
Mercedes Vanaclocha-Espi
Pilar Amiano
María Dolores Chirlaque
Vicente Simó
José J. Jiménez-Moleón
Adonina Tardón
Víctor Moreno
Gemma Castaño-Vinyals
Vicente Martín
Nuria Aragonés
Beatriz Pérez-Gómez
Manolis Kogevinas
Marina Pollán
Source :
Environment International, Vol 144, Iss , Pp 106055- (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects’ residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44–2.87) to 3 km (1.26; 1.00–1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77–4.00), surface treatment of metals (1.48; 1.08–2.02), glass and mineral fibers (2.06; 1.39–3.07), organic chemical industry (4.80; 3.20–7.20), inorganic chemical industry (6.74; 4.38–10.36), food/beverage sector (3.34; 2.38–4.68), and surface treatment using organic solvents (6.16; 4.06–9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91–14.28), antimony (5.30; 3.45–8.15), naphthalene (3.11; 2.16–4.49), organotin compounds (2.64; 1.76–3.98), manganese (2.53; 1.63–3.93), dichloromethane (2.52; 1.74–3.66), and vanadium (2.49; 1.59–3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.

Details

Language :
English
ISSN :
01604120
Volume :
144
Issue :
106055-
Database :
Directory of Open Access Journals
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
edsdoj.5233a746211d42e09e63a0a66f53189f
Document Type :
article
Full Text :
https://doi.org/10.1016/j.envint.2020.106055