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Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis

Authors :
Yan Wang
Peng Wang
Hai-Yan Cao
Hai-Tao Ding
Hai-Nan Su
Shi-Cheng Liu
Guangfeng Liu
Xia Zhang
Chun-Yang Li
Ming Peng
Fuchuan Li
Shengying Li
Yin Chen
Xiu-Lan Chen
Yu-Zhong Zhang
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The collagenolytic mechanism of Vibrio collagenase, a virulence factor, remains unclear. Here, the authors report the structure of Vibrio collagenase VhaC and propose the mechanism for collagen recognition and degradation, providing new insight into bacterial collagenolysis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.528c344068f4e9485dae7fec43b36a2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28264-1