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Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth

Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth

Authors :
Lorenza Dall'Aglio
Fernando Estévez-López
Mónica López-Vicente
Bing Xu
Oktay Agcaoglu
Elias Boroda
Kelvin O. Lim
Vince D. Calhoun
Henning Tiemeier
Ryan L. Muetzel
Source :
NeuroImage: Clinical, Vol 38, Iss , Pp 103382- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Background: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods: We adopted a longitudinal design with repeated assessments to investigate associations between functional network connectivity (FNC) and psychiatric problems in youth (9- to 17-year-olds, two time points) from the general population. The largest single-site study of pediatric neurodevelopment was used: Generation R (N = 3,131 with data at either time point). Psychiatric symptoms were measured with the Child Behavioral Checklist as broadband internalizing and externalizing problems, and its eight specific syndrome scales (e.g., anxious-depressed). FNC was assessed with two complementary approaches. First, static FNC (sFNC) was measured with graph theory-based metrics. Second, dynamic FNC (dFNC), where connectivity is allowed to vary over time, was summarized into 5 states that participants spent time in. Cross-lagged panel models were used to investigate the longitudinal bidirectional relationships of sFNC with internalizing and externalizing problems. Similar cross-lagged panel models were run for dFNC. Results: Small longitudinal relationships between dFNC and certain syndrome scales were observed, especially for baseline syndrome scales (i.e., rule-breaking, somatic complaints, thought problems, and attention problems) predicting connectivity changes. However, no association between any of the psychiatric problems (broadband and syndrome scales) with either measure of FNC survived correction for multiple testing. Conclusion: We found no or very modest evidence for longitudinal associations between psychiatric problems with dynamic and static FNC in this population-based sample. Differences in findings may stem from the population drawn, study design, developmental timing, and sample sizes.

Details

Language :
English
ISSN :
22131582
Volume :
38
Issue :
103382-
Database :
Directory of Open Access Journals
Journal :
NeuroImage: Clinical
Publication Type :
Academic Journal
Accession number :
edsdoj.52ae2a5378d40dc8bb1ca2ecec88b23
Document Type :
article
Full Text :
https://doi.org/10.1016/j.nicl.2023.103382