Back to Search Start Over

Honing-in antigen-specific cells during antibody discovery: a user-friendly process to mine a deeper repertoire

Authors :
Ankit Mahendra
Aftabul Haque
Ponraj Prabakaran
Brian C. Mackness
Thomas P. Fuller
Xiaohua Liu
Sagar V. Kathuria
Yui-Hsi Wang
Nilesh Amatya
Xiaocong Yu
Joern Hopke
Dietmar Hoffmann
Eva Bric-Furlong
Ningning Zhang
Hyun-Suk Cho
Ruijun Zhang
Jose Sancho
Jacqueline Saleh
Sambasiva P. Rao
Maria Wendt
Partha S. Chowdhury
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The authors developed a methodology for bulk enrichment of antigen-specific B cells to improve the diversity of antibody sequences and increase the number of functional antigen-specific antibodies coming from different antibody generation platforms.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.52ce13cfecd7433fa59e55c134afee54
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-04129-7