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Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity

Authors :
Md Rasel Molla
Akio Shimizu
Masahiro Komeno
Nor Idayu A. Rahman
Joanne Ern Chi Soh
Le Kim Chi Nguyen
Mahbubur Rahman Khan
Wondwossen Wale Tesega
Si Chen
Xiaoling Pang
Miki Tanaka-Okamoto
Noriyuki Takashima
Akira Sato
Tomoaki Suzuki
Hisakazu Ogita
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

RhoA is required in vascular smooth muscle cells to inhibit MAP4K4 and prevent abdominal aortic aneurysm formation.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.535be4766d674766a197e50d35d73b39
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-04042-z