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Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Authors :
Wen Fong Ooi
Manjie Xing
Chang Xu
Xiaosai Yao
Muhammad Khairul Ramlee
Mei Chee Lim
Fan Cao
Kevin Lim
Deepak Babu
Lai-Fong Poon
Joyce Lin Suling
Aditi Qamra
Astrid Irwanto
James Qu Zhengzhong
Tannistha Nandi
Ai Ping Lee-Lim
Yang Sun Chan
Su Ting Tay
Ming Hui Lee
James O. J. Davies
Wai Keong Wong
Khee Chee Soo
Weng Hoong Chan
Hock Soo Ong
Pierce Chow
Chow Yin Wong
Sun Young Rha
Jianjun Liu
Axel M. Hillmer
Jim R. Hughes
Steve Rozen
Bin Tean Teh
Melissa Jane Fullwood
Shang Li
Patrick Tan
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.537b19ccbb94c08a4be48239ebf76e6
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms12983