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The value of bronchodilator response in FEV1 and FeNO for differentiating between chronic respiratory diseases: an observational study

Authors :
Zhaoqian Gong
Junwen Huang
Guiling Xu
Ying Chen
Maosheng Xu
Yanyan Ma
Wenqu Zhao
Yanhong Wang
Jianpeng Liang
Chunquan Ou
Laiyu Liu
Shaoxi Cai
Haijin Zhao
Source :
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-10 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background There is no uniform standard for a strongly positive bronchodilation test (BDT) result. In addition, the role of bronchodilator response in differentiating between asthma, chronic obstructive pulmonary disease (COPD), and asthma–COPD overlap (ACO) in patients with a positive BDT result is unclear. We explored a simplified standard of a strongly positive BDT result and whether bronchodilator response combined with fractional exhaled nitric oxide (FeNO) can differentiate between asthma, COPD, and ACO in patients with a positive BDT result. Methods Three standards of a strongly positive BDT result, which were, respectively, defined as post-bronchodilator forced expiratory volume in 1-s responses (ΔFEV1) increasing by at least 400 mL + 15% (standard I), 400 mL (standard II), or 15% (standard III), were analyzed in asthma, COPD, and ACO patients with a positive BDT result. Receiver operating characteristic curves were used to determine the optimal values of ΔFEV1 and FeNO. Finally, the accuracy of prediction was verified by a validation study. Results The rates of a strongly positive BDT result and the characteristics between standards I and II were consistent; however, those for standard III was different. ΔFEV1 ≥ 345 mL could predict ACO diagnosis in COPD patients with a positive BDT result (area under the curve [AUC]: 0.881; 95% confidence interval [CI] 0.83–0.94), with a sensitivity and specificity of 90.0% and 91.2%, respectively, in the validation study. When ΔFEV1 was

Details

Language :
English
ISSN :
2047783X
Volume :
29
Issue :
1
Database :
Directory of Open Access Journals
Journal :
European Journal of Medical Research
Publication Type :
Academic Journal
Accession number :
edsdoj.538b9ba5e2244206be83c59f9065dec6
Document Type :
article
Full Text :
https://doi.org/10.1186/s40001-024-01679-w