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Role of atrial natriuretic peptide in the dissociation between flow relations with ventricular mass and function in a community with volume-dependent hypertension
- Source :
- Frontiers in Cardiovascular Medicine, Vol 10 (2023)
- Publication Year :
- 2023
- Publisher :
- Frontiers Media S.A., 2023.
-
Abstract
- BackgroundWhether differential effects of volume load on left ventricular mass (LVM) and function occur in sustained volume-dependent primary hypertension, and the impact of atrial natriuretic peptide (ANP) on these effects, is unknown.MethodsFrom aortic pressure, velocity and diameter measurements and echocardiography, we determined in an African community (n = 772), the impact of systemic flow-induced increases in central pulse pressure (PPc) and circulating ANP (ELISA) on LVM and indexes of function.ResultsStroke volume (SV), but not aortic flow (Q), was associated with LVM and mean wall thickness (MWT) beyond stroke work and confounders (p 0.14) and adjustments for neither SV nor Q modified relationships between PPc and s', e' or E/e' (p
Details
- Language :
- English
- ISSN :
- 2297055X
- Volume :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Cardiovascular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.53a4cf1f1144bc4be90bbefe3b2786d
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fcvm.2023.1175145