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From Azidoproline to Functionalizable Collagen
- Source :
- CHIMIA, Vol 67, Iss 12 (2013)
- Publication Year :
- 2013
- Publisher :
- Swiss Chemical Society, 2013.
-
Abstract
- The article summarizes our research devoted to the development of functionalizable collagen using azidoproline-containing model peptides. 'Click chemistry' or Staudinger reduction followed by acylation provided facile access to a range of differently functionalized collagen model peptides bearing e.g. carbohydrates. The research provided not only insight into the factors that are responsible for the high conformational stability of collagen but also a guide in which positions functional moieties are tolerated without or by deliberately disturbing the supramolecular assembly of collagen. The presented research will be useful for the development of collagen-based materials.
- Subjects :
- Cd spectroscopy
Click chemistry
Collagen
Peptides
Proline
Chemistry
QD1-999
Subjects
Details
- Language :
- German, English, French
- ISSN :
- 00094293 and 26732424
- Volume :
- 67
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- CHIMIA
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.53ceacca1664dc7a3b2bc7c4ecba9b7
- Document Type :
- article
- Full Text :
- https://doi.org/10.2533/chimia.2013.891