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From Azidoproline to Functionalizable Collagen

Authors :
Christiane Siebler
Roman S. Erdmann
Helma Wennemers
Source :
CHIMIA, Vol 67, Iss 12 (2013)
Publication Year :
2013
Publisher :
Swiss Chemical Society, 2013.

Abstract

The article summarizes our research devoted to the development of functionalizable collagen using azidoproline-containing model peptides. 'Click chemistry' or Staudinger reduction followed by acylation provided facile access to a range of differently functionalized collagen model peptides bearing e.g. carbohydrates. The research provided not only insight into the factors that are responsible for the high conformational stability of collagen but also a guide in which positions functional moieties are tolerated without or by deliberately disturbing the supramolecular assembly of collagen. The presented research will be useful for the development of collagen-based materials.

Details

Language :
German, English, French
ISSN :
00094293 and 26732424
Volume :
67
Issue :
12
Database :
Directory of Open Access Journals
Journal :
CHIMIA
Publication Type :
Academic Journal
Accession number :
edsdoj.53ceacca1664dc7a3b2bc7c4ecba9b7
Document Type :
article
Full Text :
https://doi.org/10.2533/chimia.2013.891