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Combined Application of Cold Physical Plasma and Chemotherapeutics against Chondrosarcoma Cells

Authors :
Andreas Nitsch
Sara Qarqash
Frank Schulze
Lars Nonnenmacher
Sander Bekeschus
Mladen V. Tzvetkov
Georgi I. Wassilew
Lyubomir Haralambiev
Source :
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6955 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Chondrosarcoma (CS) is a rare malignant bone sarcoma that primarily affects cartilage cells in the femur and pelvis. While most subtypes exhibit slow growth with a very good prognosis, some aggressive subtypes have a poorer overall survival. CS is known for its resistance to chemotherapy and radiotherapy, leaving surgery as the sole effective therapeutic option. Cold physical plasma (CPP) has been explored in vitro as a potential therapy, demonstrating positive anti-tumor effects on CS cells. This study investigated the synergistic effects of combining CPP with cytostatics on CS cells. The chemotherapeutic agents cisplatin, doxorubicin, and vincristine were applied to two CS cell lines (CAL-78 and SW1353). After determining their IC20 and IC50, they were combined with CPP in both cell lines to assess their impact on the cell proliferation, viability, metabolism, and apoptosis. This combined approach significantly reduced the cell proliferation and viability while increasing the apoptosis signals compared to cytostatic therapy alone. The combination of CPP and chemotherapeutic drugs shows promise in targeting chemoresistant CS cells, potentially improving the prognosis for patients in clinical settings.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
13
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.5425f3c093554a8dbaa5f6454cb754f1
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25136955