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Risk of tuberculosis in patients with rheumatoid arthritis treated with biological and targeted drugs: meta-analysis of randomized clinical trials
- Source :
- Chinese Medical Journal, Vol 135, Iss 4, Pp 409-415 (2022)
- Publication Year :
- 2022
- Publisher :
- Wolters Kluwer, 2022.
-
Abstract
- Abstract. Background:. Concerns exist regarding the potential development of tuberculosis in patients with rheumatoid arthritis (RA) treated with biological and targeted drugs. We assessed systematically whether biological therapy increased the risk of tuberculosis in patients with RA by meta-analysis of randomized controlled trials (RCTs). Methods:. A systematic literature search was conducted in PubMed, Embase, the Cochrane Library, and China Biology Medicine disc for RCTs evaluating biological therapy in patients with RA from inception through August 2021. Traditional meta-analysis and network meta-analysis were performed to compare the risk of tuberculosis for each biologics class in patients with RA. Peto odds ratio (Peto OR) and its 95% confidence interval (CI) were calculated as the primary effect measure. Results:. In total, 39 studies with 20,354 patients were included in this meta-analysis, and 82 patients developed tuberculosis. The risk of tuberculosis was increased in patients treated with biologics compared with non-biologics (Peto OR: 3.86, 95% CI: 2.36–6.32, P
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 03666999, 25425641, and 00000000
- Volume :
- 135
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Chinese Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.54600f32d05e4bff9e582a9e9beb0716
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/CM9.0000000000001948