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The Caspofungin Paradoxical Effect is a Tolerant 'Eagle Effect' in the Filamentous Fungal Pathogen Aspergillus fumigatus
- Source :
- mBio, Vol 13, Iss 3 (2022)
- Publication Year :
- 2022
- Publisher :
- American Society for Microbiology, 2022.
-
Abstract
- ABSTRACT Cell responses against antifungals other than resistance have rarely been studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasingly examined in yeast-like organisms. Aspergillus fumigatus is a filamentous fungal pathogen that causes a disease named aspergillosis, for which caspofungin (CAS), a fungistatic drug, is used as a second-line therapy. Some A. fumigatus clinical isolates can survive and grow in CAS concentrations above the minimum effective concentration (MEC), a phenomenon known as “caspofungin paradoxical effect” (CPE). Here, we evaluated the CPE in 67 A. fumigatus clinical isolates by calculating recovery rate (RR) values, where isolates with an RR of ≥0.1 were considered CPE+ while isolates with an RR of
Details
- Language :
- English
- ISSN :
- 21507511
- Volume :
- 13
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- mBio
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.546c975ccb58452ab4b40af4f36fecc6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1128/mbio.00447-22