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Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

Authors :
Mona C. Löffler
Matthias J. Betz
Denis P. Blondin
Robert Augustin
Anand K. Sharma
Yu-Hua Tseng
Camilla Scheele
Heike Zimdahl
Michael Mark
Anita M. Hennige
Christian Wolfrum
Wolfgang Langhans
Bradford S. Hamilton
Heike Neubauer
Source :
Molecular Metabolism, Vol 51, Iss , Pp 101237- (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Background: A chronic imbalance of energy intake and energy expenditure results in excess fat storage. The obesity often caused by this overweight is detrimental to the health of millions of people. Understanding both sides of the energy balance equation and their counter-regulatory mechanisms is critical to the development of effective therapies to treat this epidemic. Scope of review: Behaviors surrounding ingestion have been reviewed extensively. This review focuses more specifically on energy expenditure regarding bodyweight control, with a particular emphasis on the organs and attractive metabolic processes known to reduce bodyweight. Moreover, previous and current attempts at anti-obesity strategies focusing on energy expenditure are highlighted. Precise measurements of energy expenditure, which consist of cellular, animal, and human models, as well as measurements of their translatability, are required to provide the most effective therapies. Major conclusions: A precise understanding of the components surrounding energy expenditure, including tailored approaches based on genetic, biomarker, or physical characteristics, must be integrated into future anti-obesity treatments. Further comprehensive investigations are required to define suitable treatments, especially because the complex nature of the human perspective remains poorly understood.

Details

Language :
English
ISSN :
22128778
Volume :
51
Issue :
101237-
Database :
Directory of Open Access Journals
Journal :
Molecular Metabolism
Publication Type :
Academic Journal
Accession number :
edsdoj.54b7c6d5a695498899b3cf87dcf88710
Document Type :
article
Full Text :
https://doi.org/10.1016/j.molmet.2021.101237