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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection

Authors :
Aileen Y. Chang
Sarah Tritsch
St. Patrick Reid
Karen Martins
Liliana Encinales
Nelly Pacheco
Richard L. Amdur
Alexandra Porras-Ramirez
Alejandro Rico-Mendoza
Guangzhao Li
Jin Peng
Gary S. Firestein
Gary L. Simon
Jeff M. Bethony
Source :
Diseases, Vol 6, Iss 4, p 95 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.

Details

Language :
English
ISSN :
20799721
Volume :
6
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.54ce105fefd46b8a693c948b0d76579
Document Type :
article
Full Text :
https://doi.org/10.3390/diseases6040095