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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
- Source :
- Diseases, Vol 6, Iss 4, p 95 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.
- Subjects :
- arthritis
chikungunya
cytokine
alphavirus
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20799721
- Volume :
- 6
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.54ce105fefd46b8a693c948b0d76579
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/diseases6040095