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Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Authors :
Corina N. D’Alessandro-Gabazza
Taro Yasuma
Tetsu Kobayashi
Masaaki Toda
Ahmed M. Abdel-Hamid
Hajime Fujimoto
Osamu Hataji
Hiroki Nakahara
Atsuro Takeshita
Kota Nishihama
Tomohito Okano
Haruko Saiki
Yuko Okano
Atsushi Tomaru
Valeria Fridman D’Alessandro
Miyako Shiraishi
Akira Mizoguchi
Ryoichi Ono
Junpei Ohtsuka
Masayuki Fukumura
Tetsuya Nosaka
Xuenan Mi
Diwakar Shukla
Kensuke Kataoka
Yasuhiro Kondoh
Masaki Hirose
Toru Arai
Yoshikazu Inoue
Yutaka Yano
Roderick I. Mackie
Isaac Cann
Esteban C. Gabazza
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.55325ad1d4042ecbf6c24f945542d94
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29064-3