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Quantitative Values from Synthetic MRI Correlate with Breast Cancer Subtypes

Authors :
Toshiki Kazama
Taro Takahara
Thomas C. Kwee
Noriko Nakamura
Nobue Kumaki
Naoki Niikura
Tetsu Niwa
Jun Hashimoto
Source :
Life, Vol 12, Iss 9, p 1307 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The purpose of this study is to correlate quantitative T1, T2, and proton density (PD) values with breast cancer subtypes. Twenty-eight breast cancer patients underwent MRI of the breast including synthetic MRI. T1, T2, and PD values were correlated with Ki-67 and were compared between ER-positive and ER-negative cancers, and between Luminal A and Luminal B cancers. The effectiveness of T1, T2, and PD in differentiating the ER-negative from the ER-positive group and Luminal A from Luminal B cancers was evaluated using receiver operating characteristic analysis. Mean T2 relaxation of ER-negative cancers was significantly higher than that of ER-positive cancers (p < 0.05). The T1, T2, and PD values exhibited a strong positive correlation with Ki-67 (Pearson’s r = 0.75, 0.69, and 0.60 respectively; p < 0.001). Among ER-positive cancers, T1, T2, and PD values of Luminal A cancers were significantly lower than those of Luminal B cancers (p < 0.05). The area under the curve (AUC) of T2 for discriminating ER-negative from ER-positive cancers was 0.87 (95% CI: 0.69–0.97). The AUC of T1 for discriminating Luminal A from Luminal B cancers was 0.83 (95% CI: 0.61–0.95). In conclusion, quantitative values derived from synthetic MRI show potential for subtyping of invasive breast cancers.

Details

Language :
English
ISSN :
20751729
Volume :
12
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Life
Publication Type :
Academic Journal
Accession number :
edsdoj.5564c8cda6744521a8e81caec548a908
Document Type :
article
Full Text :
https://doi.org/10.3390/life12091307