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Strongyloides spp. and Cytomegalovirus Co-Infection in Patient Affected by Non-Hodgkin Lymphoma

Authors :
Tommaso Lupia
Elena Crisà
Alberto Gaviraghi
Barbara Rizzello
Alessia Di Vincenzo
Fabrizio Carnevale-Schianca
Daniela Caravelli
Marco Fizzotti
Francesco Tolomeo
Umberto Vitolo
Ilaria De Benedetto
Nour Shbaklo
Alessandro Cerutti
Piero Fenu
Vanesa Gregorc
Silvia Corcione
Valeria Ghisetti
Francesco Giuseppe De Rosa
Source :
Tropical Medicine and Infectious Disease, Vol 8, Iss 6, p 331 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

To our knowledge, we have described the first case of Strongyloides/Cytomegalovirus (CMV) concomitant infection that occurred in a European country. The patient was a 76-year-old woman affected by relapsed non-Hodgkin lymphoma who presented interstitial pneumonia with a rapidly progressive worsening of respiratory insufficiency, leading to cardiac dysfunction and consequent death. CMV reactivation is a common complication in immunocompromised patients, while hyperinfection/disseminated strongyloidiasis (HS/DS) is rare in low endemic regions, but has been widely described in Southeast Asia and American countries. HS and DS are two consequences of the failure of infection control by the immune system: HS is the uncontrolled replication of the parasite within the host and DS the spreading of the L3 larvae in organs other than the usual replication sites. Only a few cases of HS/CMV infection have been reported in the literature, and only in one patient with lymphoma as an underlying disease. The clinical manifestations of these two infections overlap, usually leading to a delayed diagnosis and a consequent poor outcome.

Details

Language :
English
ISSN :
24146366
Volume :
8
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Tropical Medicine and Infectious Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.5578c3298e094bba94d5063918427716
Document Type :
article
Full Text :
https://doi.org/10.3390/tropicalmed8060331