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Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification

Authors :
Yupeng Zhao
Mathilde Hauge Lerche
Magnus Karlsson
Rie Beck Olin
Esben Søvsø Szocska Hansen
Malene Aastrup
Mohsen Redda
Christoffer Laustsen
Lars G. Hanson
Jan Henrik Ardenkjær-Larsen
Source :
Tomography, Vol 10, Iss 7, Pp 1113-1122 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusions: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.

Details

Language :
English
ISSN :
2379139X and 23791381
Volume :
10
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Tomography
Publication Type :
Academic Journal
Accession number :
edsdoj.55c945ab86ed4dcf86a012cfb0dbdf2c
Document Type :
article
Full Text :
https://doi.org/10.3390/tomography10070084