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mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 47467398
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.55fa5c77ea474673980a024897c7214c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-01602-4