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DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

Authors :
Xin-Xuan Lin
Ilke Sen
Georges E. Janssens
Xin Zhou
Bryan R. Fonslow
Daniel Edgar
Nicholas Stroustrup
Peter Swoboda
John R. Yates
Gary Ruvkun
Christian G. Riedel
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.560c3b80b1d74b0b81296e799f7bb7fb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-06624-0